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| 声动力化学疗法对大鼠颅内胶质瘤的杀伤作用 | |
| 引用本文： | 宋大勇,岳武,尹立春,魏盾,林述凯,李超,李建华.声动力化学疗法对大鼠颅内胶质瘤的杀伤作用[J].中国微侵袭神经外科杂志,2011,16(8):358-361. |
| 作者姓名： | 宋大勇 岳武 尹立春 魏盾 林述凯 李超 李建华 |
| 作者单位： | 1. 北华大学附属医院神经外科,吉林,132011 2. 哈尔滨医科大学第四临床医学院神经外科,150001 3. 吉林市第六人民医院心理科,132000 |
| 基金项目： | 国家自然科学基金(编号:30970834); 黑龙江省卫生厅课题(编号:2006-206,2007-408) |
| 摘 要： | 目的探讨声动力化学疗法(SDT)对大鼠颅内胶质瘤的杀伤效应。方法制作大鼠颅内C6胶质瘤实验模型,将大鼠随机分为声动力治疗(SDT)组、超声(US)组、血啉甲醚(HMME)组、对照组,治疗后行颅内胶质瘤MRI影像学检查及组织光镜、电镜观察,并记录4组大鼠生存期。结果 MRI显示:治疗3 d、7 d后,SDT组肿瘤体积分别为(47.05±1.96)mm3、(13.02±1.15)mm3,较其他3组明显减小(均P<0.01)。光镜显示:SDT组肿瘤组织坏死于治疗后24 h达到高峰。电镜显示:治疗后24 h,SDT组见大量坏死细胞,部分细胞呈凋亡表现;US组少量细胞呈凋亡表现。SDT组生存期为52.25 d,较其他3组明显延长(均P<0.01)。结论 SDT对大鼠颅内C6胶质瘤有明显抑制效应。 |
| 关 键 词： | 神经胶质瘤 声动力化学疗法 血卟啉类 大鼠 |
Killing effect of sonodynamic therapy on rat glioma cells |
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| Song Dayong,Yue Wu,Yin Lichun,Wei Dun,Lin Shukai,Li Chao,Li Jianhua.Killing effect of sonodynamic therapy on rat glioma cells[J].Chinese Journal of Minimally Invasive Neurosurgery,2011,16(8):358-361. | |
| Authors: | Song Dayong Yue Wu Yin Lichun Wei Dun Lin Shukai Li Chao Li Jianhua |
| Institution: | Song Dayong1,Yue Wu2,Yin Lichun3,Wei Dun1,Lin Shukai1,Li Chao1,Li Jianhua2 1.Department of Neurosurgery,Affiliated Hospital of Beihua University,Jilin,Jilin 132011,China,2.Department of Neurosurgery,Fourth Clinical College,Affiliated to Harbin Medical University,Harbin,Heilongjiang 150001,3.Department of Psychology,Sixth People's Hospital of Jilin,Jilin 132000 |
| Abstract: | Objective To investigate the killing effect of sonodynamic therapy(SDT) on rat brain glioma.Methods The rat brain C6 glioma was established as experimental model.The rats were randomly divided into sonodynamic therapy(SDT) group,ultrasound(US) group,hematoporphyrin monomethyl ether(HMME) group and control group.The rat brain glioma of 4 groups was examined by MRI and the tumor tissue was observed by light microscope and electron microscope after treatment.Moreover,the rat survival time of 4 groups was recor... |
| Keywords: | glioma sonodynamic therapy hematoporphyrins rats |
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