| 川芎嗪对缺氧肺动脉高压大鼠血浆内皮素、降钙素基因相关肽水平的影响 |
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| 引用本文： | 黄志宏,汤泰秦,黄纳斯,刘升明,吴义,陈淑芬. 川芎嗪对缺氧肺动脉高压大鼠血浆内皮素、降钙素基因相关肽水平的影响[J]. 广州中医药大学学报, 1998, 0(4) |
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| 作者姓名： | 黄志宏 汤泰秦 黄纳斯 刘升明 吴义 陈淑芬 |
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| 作者单位： | 广州暨南大学附属广州华侨医院呼吸内科 |
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| 摘 要： | 用酶免疫检测法测定缺氧３周大鼠血浆内皮素－１（ＥＴ－１）、降钙素基因相关肽（ＣＧＲＰ）含量，研究缺氧肺动脉高压（ＨＰＨ）大鼠血浆ＥＴ－１、ＣＧＲＰ水平及川芎嗪对其影响。结果表明，缺氧可使血浆ＥＴ－１水平升高，血浆ＣＧＲＰ水平降低，ＥＴ－１和ＣＧＲＰ与ＨＰＨ形成密切相关，ＣＧＲＰ／ＥＴ－１比值失衡可能是ＨＰＨ发生发展的重要因素之一；川芎嗪对ＨＰＨ的形成有预防作用，此预防作用可能与纠正失衡的ＣＧＲＰ／ＥＴ－１比值有关。
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| 关 键 词： | 川芎嗪／药理学；高血压.肺性／中药疗法；川芎嗪／治疗应用；内皮缩血管肽类／血液；降钙素基因相关肽／血液 |
Effects of Ligustrazine on the Levels of Serum Endothelin_1 and Calcitonin Gene_Related Peptide in Rats with Hypoxic Pulmonary Hypertension |
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| Huang Zhihong Tang Taiqing Huang Nasi Liu Shengming Wu Yi Chen Shufen Dept. of Respiratory Disease,Affiliated Overseas Chinese Hospital of Jinan University,Guangzhou. Effects of Ligustrazine on the Levels of Serum Endothelin_1 and Calcitonin Gene_Related Peptide in Rats with Hypoxic Pulmonary Hypertension[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 1998, 0(4) |
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| Authors: | Huang Zhihong Tang Taiqing Huang Nasi Liu Shengming Wu Yi Chen Shufen Dept. of Respiratory Disease Affiliated Overseas Chinese Hospital of Jinan University Guangzhou |
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| Affiliation: | Huang Zhihong Tang Taiqing Huang Nasi Liu Shengming Wu Yi Chen Shufen Dept. of Respiratory Disease,Affiliated Overseas Chinese Hospital of Jinan University,Guangzhou 510632 |
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| Abstract: | The levels of serum endothelin_1(ET_1) and calcitonin gene_related peptide (CGRP) in rats with hypoxic pulmonary hypertension(HPH) for 3 weeks were measured by means of enzyme immunoassay and the effect of ligustrazine was studied.The results showed that the level of ET_1 increased and that of CGRP decreased in the state of hypoxia. It is concluded that the imbalance of CGRP/ET_1 ratio is probably one of the important factors of the formation and development of HPH, and the mechanism of the protective effect of ligustrazine on HPH may be related to the correction of the imbalance of the CGRP/ET_1 ratio. |
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| Keywords: | TETRAMETHYLPYRAZINE/pharmacology HYPERTENSION PORTAL/TCD therapy TETRAMETHYLPYRAZINE/therapeutic use ENDOTHELINS/blood CALCITONIN GENE_RELATED PEPTIDE/blood |
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