Konzentration Thiobarbitursäure-reaktiver Substanzen (TBARS) im Serum nach Myokardinfarkt

Summary The serum concentration of thiobarbituric acid reactive substances (TBARS), which can be used in the characterization of O₂-radical metabolism, was analyzed in patients with myocardial infarction in the acute phase, 10–14 days, 1 month, and 6 months after infarction, and compared with the TBARS concentration of a healthy group and a group with atherosclerosis. After myocardial infarction we found increased TBARS concentration at all moments of investigation in comparison with the healthy and atherosclerosis groups. Maximum concentration was found 10–14 days after infarction, afterwards the TBARS concentration decreased, without however attaining the values which we found in the comparison groups. The increased TBARS concentration 6 months after myocardial infarction demonstrates a manifestation of disturbances in the O₂-radical metabolism. Such disturbances may be regarded as a high-risk factor to the cardiovascular system.

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Abkürzungsverzeichnis AS Patienten mit Atherosklerose - ASAT Aspartataminotransferase - Ca-ATPase Calzium-abhängige Adenosintriphosphatase - CK Creatinkinase - EKG Elektrokardiogramm - K Kontrollgruppe - MDA Malondialdehyd - Na,K-ATPase Natrium-Kalium-abhängige Adenosintriphosphatase - O₂-Radikal Sauerstoffradikal - TBARS Thiobarbitursäure-reaktive Substanzen - Vit. E Vitamin E (-Tocopherol)