E-cadherin和Ki-67在结直肠癌组织中的表达及意义

 目的 探讨E-cadherin和Ki-67在结直肠癌中的表达及意义。方法 应用免疫组化SP法检测48例结直肠癌、23例结肠腺瘤和20例正常结肠组织中E-cadherin及Ki-67的表达,并分析其与结直肠癌临床病理特征的关系。结果 结直肠癌、结肠腺瘤和正常结肠组织中E-cadherin异常表达率分别为77.1%、24.0%和5.0%,结直肠癌E-cadherin异常表达率明显高于结肠腺瘤和正常结肠组织,组间比较差异有显著性（P〈0.01）。Ki-67阳性指数在结直肠癌、结肠腺瘤及正常结肠组织中分别为（67.60±2.52）%、（38.44±3.59）%及（8.65±1.10）%。结直肠癌的Ki-67阳性指数明显高于结肠腺瘤和正常结肠组织,组间两两比较差异有统计学意义（P〈0.01）。E-cadherin表达与浸润深度和有无淋巴转移有关（P=0.020和P=0.013）,而与患者的年龄、性别、大体形态、分化程度无关。Ki-67表达与患者性别和有无淋巴转移有关（P=0.011和P=0.043）,而与患者的年龄、大体形态、分化程度、浸润深度无关。E-cadherin正常表达组和异常表达组的Ki-67阳性指数分别为（67.30±18.87）%和（68.64±11.99）%。E-cadherin异常表达组Ki-67阳性指数略高于正常表达组,但无统计学意义。结论 E-cadherin和Ki-67是结直肠癌发生发展过程中的重要因子,并与结直肠癌浸润转移有关,可作为评估结直肠癌预后、指导治疗的指标,但两者在结直肠癌发生、发展、侵袭和转移过程中没有协同作用。

Expression and Significance of E-cadherin and Ki-67 in Colorectal Carcinoma

Objective To study the expression and significance of E-cadherin and Ki-67 in colorectal carcinoma. Methods Forty-eight colorectal carcinomas,23 colorectal adenoma and 20 normal colorectal tissues were envolled in this study. Immunohistochemistry method was used to detect the expressions of E-cadherin and Ki-67, then their relationship with the clinicopathological features of colorectal carcinomas was analyzed. Results The abnormal rate of E-cadherin in colorectal carcinomas (77.1%) was much higher than tha...