Marked effects of extreme levels of lipoprotein(a) on estimation of low-density lipoprotein cholesterol |
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Authors: | Ramesh Saeedi Min Li Matt Allard Jiri Frohlich |
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Institution: | Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada |
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Abstract: | BackgroundLow-density lipoprotein cholesterol (LDL-C) is usually calculated using the Friedewald equation. However, this calculation method does not account for the cholesterol associated with lipoprotein(a) Lp(a)]. Using the Dahlen equation, Li et al. have shown a strong positive correlation between serum Lp(a) levels and overestimation of LDL-C levels.ObjectiveTo determine how the extreme levels of Lp(a) influence the LDL-C calculation.MethodsWe performed a retrospective chart review of the lipid profile and Lp(a) of 223 patients (men and women). LDL-C was calculated using the Friedewald equation. Lp(a) concentrations were measured by an ELISA. Other serum lipids were measured enzymatically by standard methodology. Corrected LDL-C was calculated using the Dahlen equation.ResultsWe found that this overestimation is very significant in individuals with extreme levels of Lp(a) (mean overestimation of 40% at Lp(a) > 1200 mg/L).ConclusionsCalculated LDL-C is markedly overestimated in patients with extreme levels of Lp(a). |
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Keywords: | Lipoprotein(a) Dahlen equation Friedewald equation LDL-C |
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