儿童肺结核病患者血清IL-2、SIL-2R和VEGF水平及临床意义

目的:探讨了儿童肺结核病患者血清白细胞介素-2(IL-2)、可溶性白细胞介素-2受体(SIL-2R)和血管内皮生长因子(VEGF)水平的变化及意义。方法:分别应用放射免疫分析和ELISA对68例儿童肺结核病患者进行了血清IL-2、SIL-2R和VEGF水平观察,并与35名正常健康人作比较。结果:活动性儿童肺结核病患者血清IL-2水平显著低于正常儿组(P<0.01),而SIL-2R和VEGF水平显著高于正常儿组(P<0.01)。结论:测定儿童肺结核病患者血清IL-2、SIL-2R和VEGF水平更有助于儿童肺结核病活动性的检测,对该病的预防和预后均有一定的意义。

(VEGF)Clinical Significance of the Changes of Serum IL-2, SIL-2R and VEGF Levels in Pediatric Patients with Pumorary Tuberculosis

Objective To explore the clinical significance of the changes of serum IL-2,soluble IL-2 receptor(SIL-2R) and vascular endothelial growth factor(VEGF) levels in pediatric patients with tuberculosis.Methods Serum IL-2(with RIA) and SIL-2R,VEGF(with ELISA) levels were determined in 68 pediatric patients with tuberculosis (30 active and 38 non-active) and 30 controls.Results In the patients with active tuberculosis,the serum IL-2 levels were significantly lower and SIL-2R,VEGF levels were significantly higher than those in the controls(P<0.01).Conclusion Determination of serum IL-2,SIL-2R and VEGF levels was useful for monitoring the activity of tuberculosis in pediatric patients.