热休克蛋白10在大肠癌的表达及其临床病理意义

目的研究热休克蛋白10(heat shock protein 10,HSP10)在大肠癌发生、发展过程中的表达规律,了解其与大肠癌临床病理特征和术后生存期的关系。方法应用免疫组化EnVision二步法,检测HSP10在大肠正常黏膜、腺瘤和腺癌中的表达,及其与临床病理表现和术后生存期的相关性。结果HSP10在大肠正常黏膜、腺瘤和腺癌中均有表达,在腺瘤、腺癌中的表达明显强于正常黏膜(P<0.001);HSP10的阳性表达与大肠癌患者的年龄、性别、肿瘤浸润深度、局部淋巴结转移、远处转移、临床分期、组织学分化程度等临床病理特征和术后生存期均无关。结论HSP10在大肠腺瘤和腺癌的高表达,提示可能与大肠癌的发生发展有关;HSP10的阳性表达与大肠癌的临床病理特征和术后生存期无关。

Expression of heat shock protein 10 in large bowel carcinoma and its clinical significance

Objectives To investigate the expression of heat shock protein 10(HSP10) during genesis and development of large bowel carcinoma to know its clinical significance.Methods The expression of HSP10 was examined in specimens from normal colonic mucosa,colorectal adenomas and adenocarcinomas by immunohistochemistry EnVisionTM.Its correlations to clinicopathologic features,as well as to postoperative survival time of large bowel carcinoma patients were analyzed.Results The expression of HSP10 was common in normal colonic mucosa,colorectal adenomas and adenocarcinomas and was more intensive in colorectal adenomas and adenocarcinomas than in normal colonic mucosa(P< 0.001).The positive expression of HSP10 had no correlation to clinicopathologic features,including age,gender,primary tumor,infiltration of regional lymph node,metastasis,clinical stage and histopathology of large bowel carcinoma patients,as well as to their postoperative survival time.Conclusions HSP10 is overexpressed in adenoma and adenocarcinoma,suggesting that it may be related to the genesis and development of colorectal adenocarcinoma.The positive expression of HSP10 has no correlation to clinicopathologic features or postoperative survival time of large bowel carcinoma patients.