Janus-like effects of type I interferon in autoimmune diseases |
| |
Authors: | Axtell Robert C Raman Chander |
| |
Affiliation: | Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305-5316, USA. axterobe@stanford.edu |
| |
Abstract: | In multiple sclerosis, type I interferon (IFN) is considered immune-modulatory, and recombinant forms of IFN-β are the most prescribed treatment for this disease. This is in contrast to most other autoimmune disorders, because type I IFN contributes to the pathologies. Even within the relapsing-remitting multiple sclerosis (RRMS) population, 30-50% of MS patients are non-responsive to this treatment, and it consistently worsens neuromyelitis optica, a disease similar to RRMS. In this article, we discuss the recent advances in the field of autoimmunity and introduce the theory explain how type I IFNs can be pro-inflammatory in disease that is predominantly driven by a Th17 response and are therapeutic when disease is predominantly Th1. |
| |
Keywords: | interferon Th17 Th1 autoimmunity IL-7 |
本文献已被 PubMed 等数据库收录! |
|