Blood copper and serum enzyme changes following copper calcium E.D.T.A. administration to hill sheep of low copper status

Changes in blood copper and serum enzyme levels following copper calcium complex of ethylene diamine tetra acetic acid administration were studied in ewes in 3 hill flocks of low copper status and with a history of swayback. Blood copper levels increased within a few hours of injection in all the sheep and in some animals from 2 flocks there was a release of liver-specific enzymes into the blood 24 to 48 hours after dosing. Three animals died within 36 hours of injection.