儿童特发性高钙尿症与家族泌尿系结石的关系

我们采用目前国际上通用的筛查高钙尿症的方法，检测５７０名７～１４岁儿童，发现尿钙与尿肌肝（Ｃａ／Ｃｒ）比值呈偏态分布，中位值为０．０８１，第９５百分位值为０．２６，对尿Ｃａ／Ｃｒ比值大于０，２６的３１名儿童，测定２４小时尿钙定量，其中１６例２４小时尿钙大于４ｍｇ／ｋｇ，可确诊为特发性高钙尿症（ＩｄｉｏｐａｔｈｉｃＨｙｐｅｒｃａｌｃｉｕｒｉａ，ＩＨ），本组儿童ＩＨ检出率为２．８％，对此１６例经口服钙负荷测试，发现其中１１例是吸收型（ａＩＨ），４例为肾型（ｒＩＨ）。禁食时尿Ｃａ／Ｃｒ比值为０．１１７±０．０５３，服钙后增至０．３４２±０．０９２，较服钙前有非常显著升高。１６例ＩＨ家族调查发现，９名有泌尿系结石家族史，提示ＩＨ与家族泌尿系结石和本地区泌尿系结石发病有密切关系。

THE RELATION BETWEEN IDIOPATHICHYPERCALCIURIA IN CHILDREN AND THEFAMILIAL UROLITHIASIS

he urine samples of 570 children at theage of 7-14 were tested by the internationalscreening method. The value of 95th per centileof the urine Ca/Cr ratio was 0 .26. Twenty-four-hour urinary calciurn excretion were measuredin 31 children whose urine Ca/Cr ratios weregreater than 0.26, a greater than 4mg/kg/24hof urinary calcium excretion was in 16 of them.A diagnosis of idiopatbic hypercalciuria (IH)was established in these 16 children. The inci-dence of iH was 2.8% on these 570 children.A standard oral calcium test was given to th-cse 16 children and found that 11 and 4 wereabsorptive type (aIH) and renal type (rIH)respectively. The family investigation showsthat 9 of 16 IH children have family historyof urolithiasis. All of these show that the IHand the family history of urolithiasis are clo-sely related to the local urolithiasis.