理气活血中药防治大鼠血管内皮细胞损伤的实验研究

目的 观察理气活血中药对大鼠血管内皮细胞（VEC）损伤的防治作用。方法 建立大鼠VEC损伤模型，SD大鼠30只，随机分为正常对照组，模型组，理气活血组，每组各10只。检测并比较循环内皮细胞（CEC）计数，t-PA,PAI活性，6-keto-PGF1α含量及血小板最大聚集率（PAgTmax)等指标变化。结果 理气活血组与模型组比较，CEC计数明显减少（P＜0．01）；t -PA活性明显增强（P＜0．01），PAI活性降低（P＜0．05），活性型t-PA升高（P＜0．01）；6-keto-PGF1α含量升高（P＜0．01）；PAgTmax下降（P＜0．01）。结论 理气活血中药能增强VEC的抗凝及促纤溶功能，具有良好的VEC保护作用。

Experimental study of the Chinese herbs of Li Qi Huo Xue on preventing and treating the vascular endothelial cells injury in ratsl

Aim To establish a model of the injury of the vascular endothelial cell(VEC) in rats and observe the function of Chinese herbs of Li Qi Huo Xue (LQHX) will prevent and treat the VEC injury. Methods 30 SD rats were divided into the control, the model and LQHX groups. The model of the VEC injury was established. It tried to demonstrate the effect of LQHX for the coagula tion and fibrinolysis function of the VEC by the C EC count, t-PA, PAI activity, 6-keto-PGF1α content and PAgTmax. Results In LQHX group as compared with those of the medol group, The CEC count was redued obviously(P＜0.01). t-PA activity was increased (P＜0.01), so did the percentage of active t-PA(P＜0.01), but PAI activity decreased (P＜0.05), 6-keto-PGF1α content increased (P＜0.01)α the PAgTmax decreasd (P ＜0.01) Conclution LQHX can enhance the anticoagulation and fibrinolysis activities. It is a more effective measure for the VEC protection.