难治性精神分裂症患者临床特点

目的：探讨难治性精神分裂症患的临床特点。方法：在533例住院分裂症患(男性328例、女性205例)中有113例符合难治性标准的患人研究组。对照组则按照与研究组1：1的比例，分别在不同性别的非难治性精神分裂症患随机选取。对研究组与对照组的临床资料进行比较。结果：113例难治性精神分裂症患中男性有76例、女性有37例，总的难治性比率为21．20％。研究组与对照组相比。在受教育年限、首发年龄、治疗前病程、病程、住院次数、服药依从性、社会支持方面的差异有显性意义，而家庭经济水平方面差异无显意义。两组患在起病方式、病程特点、症状特点及诊断分型4个因素方面差异也有显性意义，而在性格、家族史上的差异则无显性意义。Logistic回归分析显示服药依从性、社会支持、诊断分型、症状特点、住院次数、病程特点6个因素对分裂症患疗效影响有显意义。结论：分裂症患难治的原因既有生物学因素，也有社会心理因素，在治疗分裂症患时应注意多因素的影响。

The Clinical Characters of the Patients with Treatment-Resistant Schizophrenia

Objective: To investigate the clinical characters of the patients with treatment-resistant schizophrenia. Methods:There were 113 patients with schizophrenia meeting the criteria of treatment-resistant schizophrenics in 533 schizophrenic inpatients (male 328, female 205). The patients of control group were selected randomly in the paients with treatment non-resistant schizophrenia according to the ratio of 1:1 in different sex patients respectively. Results: There were 76 male patients and 37 female patients in the study group. The percentage treatment-resistant schizophrenics in all the schizophrenics was 21.20%. The patients of study group were significant less education, earlier age at onset, longer length of episode prior to treatment, longer length of the illness, more frequency of hospitalization, better compliance and better social support than those of the control group. There was not significant difference in the level of family economy between two groups. Form of onset, type of course, features of symptoms and diagnostic subtype were statistically different between the two groups; personality and family history of mental illness were not. By the logistic analysis, these factors such as compliance, social support, diagnostic subtype, features of symptoms, hospitalization times, type of course, have significant influence to the clinical effects of the schizophrenics. Conclusions: The clinical effects of schizophrenics were influenced by both the psychosocial and biological factors. We should pay attention to those factors in clinic.