乳腺癌组织学分级与ER、PR、CerbB-2、Ki-67表达的关系

目的探讨乳腺癌组织学分级与雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体-2（CerbB-2）、Ki-67表达的相关性。方法用免疫组织化学法测定169例乳腺癌组织中ER、PR、CerbB-2、Ki-67的表达;Bloom-Richardson系统Nottingham改良方案测定组织学分级。结果169例患者ER、PR、CerbB-2和Ki-67表达的阳性率分别为56.21%、63.91%、54.44%和75.15%;Ⅰ、Ⅱ、Ⅲ级乳腺癌组织中ER、PR的阳性表达率间差异无显著性意义（P〉0.05）;随着组织学分级的递增CerbB-2、Ki-67的阳性表达率随之增加（P〈0.05）;ER的表达与CerbB-2、Ki-67的表达间有相关关系（P〈0.05）。结论乳腺癌组织中ER、PR的表达不随组织学分级的增加而增加;CerbB-2、Ki-67的表达随组织学分级的增加而增加;ER的表达与CerbB-2呈负相关,而与Ki-67呈正相关。

Relation of histological grade with expressions of ER,PR,CerbB-2 and Ki-67 in breast cancer

Objective To investigate the correlation between histological grade and expression of estrogen receptor（ER）, progesterone receptor （PR）,CerbB-2 and Ki-67. Methods The expressions of ER,PR,CerbB-2 and Ki-67 in 169 cases breast cancer were detected by immunohistochemieal method.Histological grade were detected by modified Mottingham of Bloom-Richardson system. Results The positive expressions of ER,PR,CerbB-2 and Ki-67 were 56.21% ,63.91% ,54.44% and 75.15%.There was no significant difference in positive expression rates of ER and PR among grade Ⅰ, Ⅱand Ⅲ（P〉0.05）, but the expressions of CerbB-2 and Ki-67 increased with the rise of histological grade （P〈0.05）.The expressions of ER and PR were correlated with CerbB-2 expression（P〈0.05）. Conclusion The expressions of ER and PR do not obviously change with increase of histological grade in breast cancer, but the expressions of CerbB-2 and Ki-67 do.The expression of ER is negatively correlated with CerbB-2 expression,but positively with Ki-67 expression.