肝硬化患者血浆凝血酶原时间和血清肝纤维化指标与Child—Pugh分级的关系 |
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引用本文: | 文道林,吴少卿,曹文平.肝硬化患者血浆凝血酶原时间和血清肝纤维化指标与Child—Pugh分级的关系[J].中国航天工业医药,2009(3):92-94. |
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作者姓名: | 文道林 吴少卿 曹文平 |
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作者单位: | 广东省深圳市光明新区公明医院,518106 |
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摘 要: | 目的探讨肝硬化患者血浆凝血酶原时间(PT)、血清肝纤维化指标(PC-Ⅲ、Ⅳ-C、LN、HA)与Child—Pugh肝功能分级的关系。方法按Child—Pugh分级标准将100例肝硬化患者分为A、B、C三级组,测定血浆胛、血清肝纤维化4项指标(PC-Ⅲ、Ⅳ-C、LN、HA)水平。结果A、B、C三级组血浆町、血清肝纤维化标志物水平随Child—Pugh积分增加而呈上升趋势,三组比较均有显著性差异(P〈0.05),血浆胛、血清肝纤维化指标与Child—Pugh分级之间均存在显著正相关性(r=0.359~0.604,P〈0.05)。结论联合检测肝硬化患者血浆PT和血清肝纤维化4项指标对指导肝功能Child—Pugh分级具有很好的参考价值,是较理想的实验室诊断肝硬化的指标。
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关 键 词: | 肝硬化 血浆凝血酶原时间 血清肝纤维指标 Child—Pugh分级 |
Relationship of Chiid-Pugh class with plasma prothrombin time and serum liver fibrosis indexes in patients with cirrhosis |
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Authors: | Wen Daolin Wu Shooqing Cao Wenping |
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Institution: | (Gongming Hospital of Guangming New Area, Shenzhen 518106) |
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Abstract: | Objective To investigate the relationship of Child-Pugh class with plasma prothrombin time(PT) and serum liver fibrosis indexes in patients with cirrhosis. Methods 100 patients with cirrhosis of liver were divided into stage A, B and C according to Child-Pugh staging. The plasma PT and serum liver fibrosis indexes were measured. Results Plasma PT and serum PC-m ,IV-C,LN and HA level with Child-Pugh score increased and raised,A,B and C grade compared the difference was significant (P〈0.05). The plasma PT and serum liver fibrosis indexes with the Child-Pugh class have relevance (r=0.359- 0.604,P〈0.05). Conclusion Measuring the plasma PT and serum liver fibrosis indexes(PC-HI ,IV-C,LN,HA)have an important reference value for guiding Child-Pugh class and are better indicators of laboratory diagnosis in patients with cirrhosis. |
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Keywords: | Liver cirrhosis Plasma prothrombin time Serum liver fibrosis index Child-Pugh class |
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