| 基质金属蛋白酶-9在乳腺癌组织中的表达及生物学意义 |
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| 引用本文： | 顾丽琴,邓海贞,任苏勤,柴玉海,谢芳. 基质金属蛋白酶-9在乳腺癌组织中的表达及生物学意义[J]. 中国航天工业医药, 2009, 0(2): 1-3 |
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| 作者姓名： | 顾丽琴 邓海贞 任苏勤 柴玉海 谢芳 |
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| 作者单位： | [1]江苏省太仓中医院病理科,215400 [2]苏州大学医学部病理与病理生理系,215400 |
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| 基金项目： | 基金项目：国家自然科学基金（Q3134302）及苏州大学博士基金（Q3134302） |
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| 摘 要： | 目的研究基质金属蛋白酶-9（MMP-9）的表达及其与肿瘤临床病理参数之间的关系。方法采用免疫组织化学方法检测109例乳腺癌组织和60例乳腺良性肿瘤组织中的MMP-9的表达并对结果进行分析。结果①109例乳腺癌组织中MMP-9的表达率是40.4%（44/109）,明显高于良性乳腺肿瘤（0.0%）,两者比较差异有统计学意义（P〈0.01）。②MMP-9的表达与病理分级以及临床分期密切相关,随肿瘤直径增大以及肿瘤分期的增加,MMP-9蛋白的阳性表达率也明显增加,差异有统计学意义（P〈0.05）。结论MMP-9蛋白在乳腺癌组织中高表达与乳腺癌局部浸润及预后密切相关,可作为判断乳腺癌预后的重要指标。
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| 关 键 词： | 基质金属蛋白酶-9 乳腺癌 免疫组织化学方法 |
Expression and significance of MMP-9 in breast cancer |
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| Affiliation: | Gu Liqin, Deng Haizhen, Ren Suqin, et al(Department of Patholo- gy of Taicang Chinese Medicine Hospital, Taicang 215400 ) |
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| Abstract: | Objective To investigate the expression of matrix metalloproteinase-9 （MMP-9） in breast cancer and its relationship with the clinical characteristics of tumors. Methods 109 cases of breast cancer tissues by immunobistochemistry for MMP-9, and were compared with the results with those in 60 benign tumor tissues. Results （~ The expression rate of MMP-9 protein was 40.4% in 109 cases of breast cancer. It was much higher than that in benign tumor tissues samples. The difference was statistically significant （P〈0.01）. ~） The expression of MMP-9 was related with tumor grade and TNM stage （P〈 0.05）. Conclusion The high expression of MMP-9 in breast cancer is closely related to invasion of breast cancer. It can be used as an important factor in judging the prognosis of breast cancer. |
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| Keywords: | Matrix metalloproteinase-9 Breast cancer Immunohistochemistry |
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