基质金属蛋白酶-9及高敏C反应蛋白测定对恶性大脑中动脉梗死的预测意义

目的 探讨内皮损伤标志物基质金属蛋白酶-9（MMP-9）及血清高敏C反应蛋白（hsCRP）在急性大脑前循环区脑梗死临床进展为恶性大脑中动脉梗死（m-MCAI）的作用机制.方法 收集大脑前循环区脑梗死患者90例,其中46例进展为m-MCAI.在患者入院时,以ELISA和免疫比浊法检测患者血浆MMP-9和hsCRP,并结合患者NIHSS评分及早期头颅CT改变进行分析.结果 入院时,m-MCAI患者血浆MMP-9（242.0±58.0）ng/ml明显高于非m-MCAI患者（169.0±50.0）ng/ml（P〈0.01）,m-MCA患音血浆hsCRP（6.25±1.2）mg/ml明显高于非m-MCAI患者（1.55±0.9）mg/ml（P〈0.01）.结论 早期头颅CT检查结果及血浆MMP-9、hsCRP水平增高对预测m-MCAI进程有一定意义.

Prediction of malignant middle cerebral artery infarction by plasma MMP-9 and hsCRP level

Objective To evaluate the predicting value of the marker of endothelial injury: plasma matrix metalloproteinase-9( MMP-9) and high sensitivity C-reactive protein( hsCRP) level on the progression of acute anterior circulating territory infarction progressing to malignant middle cerebral artery infarction (m-MCAI). Methods 90 patients with acute anterior circulating territory infarction, in which 46 patients progressed to m-MCAI, were collected and sampled consecutively. The plasma MMP-9 and hsCRP of all patients were determined by ELISA and immunotur-bidimetry,respectively,at admission. And the clinical characters and cranial CT features of the patients were analyzed. Results At admission,the plasma MMP-9 level in the patients with m-MCAI(242.0 ±58.0)ng/ml was significantly higher than that in the patients with non m-MCAI( 169.0 ± 50.0) ng/ml( P < 0. 01) ,the plasma hsCRP level in the patients with m-MCAI(6.25 ±1.2) ng/ml was significantly higher than that in the patients with non m-MCAI( 1.55 ± 0.9) mg/ml( P <0. 01).Conclusion The increased level of plasma MMP-9 and hsCRP could be predictors for the m-MCAI proceeding.