心可舒片与倍他乐克对冠心病患者动脉弹性影响的对照研究

目的探讨心可舒片与倍他乐克对冠心病患者动脉弹性的影响。方法选取2006年1月至11月北京大学人民医院心脏中心50例经冠状动脉造影确诊为冠心病的患者,随机分为两组,每组25例,两组患者除常规冠心病治疗外,一组给予心可舒片,另一组给予倍他乐克片,治疗持续8周,分别观察患者治疗前后血压、心率、大动脉顺应指数(C1)、小动脉震荡指数(C2)、颈-桡动脉的脉搏波传导速度(PWV)的变化。结果与治疗前相比,倍他乐克组的血压较心可舒组明显降低(P<0.05)。两组患者治疗后心率皆明显下降(P<0.05),倍他乐克组与心可舒组心率下降趋势无明显差异。治疗后在C1、C2及颈-桡动脉的PWV改善方面心可舒组优于倍他乐克组(P<0.05)。结论心可舒片可改善冠心病患者的大小动脉震荡指数、减慢脉搏波传导速度。

A clinical control study of Xin-ke-shu and Betaloc on improving arterial elasticity in the treatment of coronary heart disease

Objective To evaluate the effects of Xin-ke-shu and Betaloc on arterial elasticity of coronary heart disease(CHD).Methods According to the results from coronary angiography,50 patients who were taking long-term treatment of coronary artery obstructions were enrolled and divided into two groups in equal number at random.They were divided into Xin-ke-shu group(n=25)and Betaloc group(n=25).The Xin-ke-shu group received Xin-ke-shu(12/d)individually and the Betaloc group received Betaloc(50mg/d)for eight weeks.Patient's heart rate was measured by the doctor.Brachial blood pressure was measured by standardized mercury cuff sphygmomanometer.Automatic pulse wave velocity(PWV)measurement system and Complior Colson device and DO-2020 were applied to examine the carotid-radial artery PWV(PWVcr)and the large arterial elastic indexes(C1 and C2)respectively.Results After eight weeks of treatment.All patient's heart rate showed significant decrease.The Betaloc group,after excluded the betaloc effect,showed significant decrease of blood pressure.The Xin-ke-shu group showed significant increase of C1 and C2,and PWVcr slowed down obviously.Conclusion Xin-ke-shu improves the small and large arterial elasticity,and attenuates the wave reflex amplitude.