| 脑膜炎球菌疫苗的研究和开发现状 |
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| 引用本文： | 江元翔,朱为.脑膜炎球菌疫苗的研究和开发现状[J].国际生物制品学杂志,2009,32(4). |
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| 作者姓名： | 江元翔 朱为 |
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| 作者单位： | 上海生物制品研究所第三研究室,200052 |
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| 摘 要： | 流行性脑脊髓膜炎(流脑)是一个世界性公共卫生问题,发病率和死亡率都较高.此文从细菌遗传学特征、流脑的流行趋势、疫苗供应现状、可供选择的候选疫苗及其筛选方法等方面讨论了脑膜炎球菌疫苗(特别是B群脑膜炎球菌疫苗)的研究和开发现状.
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| 关 键 词： | 奈瑟球菌 脑膜炎 疫苗 结合 外膜囊 |
Current status of research and development of meningococcal vaccines |
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| JIANG Yuan-xiang,ZHU Wei.Current status of research and development of meningococcal vaccines[J].International Journal of Biologicals,2009,32(4). |
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| Authors: | JIANG Yuan-xiang ZHU Wei |
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| Abstract: | Meningococcal disease remains a major public health problem throughout the world,with associated high levels of morbidity and mortality.In this review,research and development of meningococcal vaccines and group B meningococcal vaccine in particular are discussed in the following aspects,including bacterial genetics,epidemic of meningococcal disease,vaccine supply,new candidate vaccines and new methods to identify meningococcal vaccine candidates. |
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| Keywords: | Neisseria meningitidis Vaccines conjugate Outer membrane vesicle |
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