| 洛汀烟酸缓释片中两组分的含量测定 |
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| 引用本文： | 吕凌,刘羽,李珠婧,陆忠祥,孙备,费勤志.洛汀烟酸缓释片中两组分的含量测定[J].中国药业,2008,17(4):27-29. |
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| 作者姓名： | 吕凌 刘羽 李珠婧 陆忠祥 孙备 费勤志 |
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| 作者单位： | 安徽省药物研究所,安徽,合肥,230022 |
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| 摘 要： | 目的建立复方洛汀烟酸缓释片中洛伐他汀和烟酸的含量测定方法。方法采用高效液相色谱（HPLC）法，色谱柱为ODS柱（250mm×4．6mm，5μm）；流动相为水-乙腈-四丁基氢氧化铵（80．5：18：1．5）；检测波长为263nm；流速为1．0mL／min；进样量为20μL。结果洛伐他汀和烟酸的质量浓度线性范围分别为25～150μg／mL和25～250μg／mL，平均回收率分别为100．1％和99．22％，RSD分别为1．5％和1．37％。结论HPLC法准确可靠，简单可行，可用于复方洛汀烟酸缓释片的质量控制。
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| 关 键 词： | 复方洛汀烟酸缓释片 洛伐他汀 烟酸 高效液相色谱法 |
| 文章编号： | 1006-4931(2008)04-0027-03 |
| 修稿时间： | 2007年6月26日 |
Determination of Lovastain and Nicotinic Acid in Compound Lovastatin-Nicotinic Acid Sustained-Release Tablets |
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| Lv ling,Liu Yun,Li Zhujing,Lu Zhongxiang,Sun Bei,Fei Qinzhi.Determination of Lovastain and Nicotinic Acid in Compound Lovastatin-Nicotinic Acid Sustained-Release Tablets[J].China Pharmaceuticals,2008,17(4):27-29. |
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| Authors: | Lv ling Liu Yun Li Zhujing Lu Zhongxiang Sun Bei Fei Qinzhi |
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| Institution: | (Anhui Institute of Materia Medica, Hefei, Anhui, China 230022) |
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| Abstract: | Objective To establish the determination method of lovastatin and nicotinic acid in Compound Lovastatin - Nicotinic Acid Sustainde - Release Tablet. Methods ODS column （250 mm × 4.6 mm, 5μm） with water - acetonitrile - tetrabutyl ammonium hydroxide （80. 5 ： 18 ： 1, 5） as the mobile phase was used. The wavelength was at 265 nm and the flow rate was 1.0 mL/min. Results The lovastatin and nicotinic acid curves were linear at the ranges of 25 - 150 μg/mL and 25 - 250 μg/mL. The average recovery rates were 100. 1% with RSD 1.5% for lovastatin and 99.22% with RSD 1.37% for nicotinic acid. Conclusion This method is reliable and simple. It can be used for the quality control of Compound Lovastatin- Nicotnic Acid Sustained- Release Tablet. |
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| Keywords: | Compound Lovastatin - Nicotinic Acid Sustained - Release Tablet lovastain nicotinic acid HPLC |
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