The effects of calcium antagonists and prostaglandin El on isolated canine coronary arterial tension |
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Authors: | Katsuhiko Yoshida Jinichi Iwase Fumihiko Murakami Akihiko Usui Michiaki Hibi Mitsuo Kawamura |
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Affiliation: | (1) Department of Cardiovascular Surgery, Owari Hospital, 2135 Kariyasuka, Yamato-cho, chinomiya, 491 Aichi, Japan |
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Abstract: | The effects of calcium antagonists (nifedipine, nicardipine, diltiazem, and verapamil) and prostaglandin E1 (PGE1) on the tension of isolated canine coronary arterial strips were studies. In a solution containing 20 mEq/L of K+, 127 mEq/L of Na+, the tension was increased by 500–1,000 mg with 4 mEq/L of Ca2+. This increase in tension was suppressed by Ca-antagonists and PGE1 dose-dependently. Nifedipine 10–5M, nicardipine 3 X 10–7M, diltiazem 3 X 10–6M, and verapamil 3 X 10–6M completely suppressed the increased tension. The maximal suppression of the tension produced by PGE1 was about 40% at 10–10M. In 20 mEq/L K+ solution (0 mEq/L Ca2+, 37°C), the reduction of the Na+ concentrations from 127 mEq/L to 12 mEq/L increased the tension by 50 to 100 mg. This increase in tension was not suppressed by Ca-antagonists or PGEI. In conclusion, this study demonstrated that Ca-antagonists and PGE1 suppressed an increase in the tension caused by Ca2+ but did not suppress an increase in the tension caused by Na+ reduction. |
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Keywords: | coronary artery contraction Ca-antagonist prostaglandin E1 |
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