草酸铂治疗晚期胃癌疗效观察

目的 :观察草酸铂 (L OHP)联合5 -氟尿嘧啶 ( 5 FU )和甲酰四氢叶酸钙(CF)在治疗晚期胃癌中的作用。方法 :L OHP 13 0mg/m2 静脉滴入 ,持续 2h ,d1;CF 10 0mg/m2 静脉滴入 ,d1～d5,5 FU 3 75mg/m2 静脉滴入 ,d1～d5。 2 1d重复。结果 :2 2例患者中 ,完全缓解 (CR) 1例 ,部分缓解 (PR) 12例 ,稳定 (NC) 5例 ,进展 (PD)4例 ,有效率 (CR PR) 5 9 0 9%。毒副反应均比较轻 ,毒性特点是外周神经感觉异常 ,症状可逆。结论 :L OHP联合 5 FU(CF)方案应用于治疗晚期胃癌可以获得比较高的疗效 ,显著提高患者生活质量

Clinical study of oxaliplatin in treatment of advanced gastric carcinoma

OBJECTIVE:To evaluate the efficacy and adverse of oxaliplatin combination with fluorouracil and leucovorin in the treatment of advanced gastric carcinoma. METHODS: Oxaliplatin was administered as a 2-hour infusion at a dose of 130 mg/m 2 on day 1; leucovorin 100 mg/m 2 on day 1 to 5; fluorouracil 375 mg/m 2 on day 1 to 5. The schedule was repeated every 21 days, with at least two cycles. RESULTS: Twenty-two patients were evaluable for treatment outcome. One obtained CR, 12 PR, 5 NC, 4 PD, and the overall response rate was 59.10%. A dose-related and reversible peripheral sensory neuropathy was the dose-limiting toxicity. The adverse reaction was tolerable. CONCLUSIONS: The oxaliplatin combination with fluorouracil and leucovorin is a highly effective regimen for patients with advanced gastric carcinoma, with a manageable toxicity.