亚砷酸注射液抗炎与镇痛作用的研究

目的 探讨亚砷酸注射液的抗炎与镇痛的药效。方法 采用测定二甲苯致小鼠耳肿胀度，测定Freund’s完全佐剂性关节炎大鼠两侧后肢足跖肿胀度，大鼠体重及脾脏、胸腺、肾上腺、髂淋巴结的脏器指数的方法，观察亚砷酸注射液的抗炎作用；采用乙酸致小鼠扭体反应，观察亚砷酸注射液的镇痛效果。结果 亚砷酸注射液对二甲苯诱发的小鼠耳急性炎性耳肿胀有显著抑制作用；治疗性给予亚砷酸注射液(4mg／kg)第5、8天，对佐剂关节炎注射侧足肿胀及另一侧后肢免疫炎性或迟发性超敏反应引起的足肿胀均有显著的抑制作用；关节炎评分显示，亚砷酸注射液对佐剂关节炎损害具有显著的保护作用；亚砷酸注射液对乙酸诱发小鼠疼痛性扭体反应也有显著的抑制作用。结论 亚砷酸注射液具有抗炎与镇痛效用。

Study on anti-inflammatory and analgesic effects of arsenous acid injection

Objective To explore anti-inflammatory and analgesic effects of arsenous acid (AA) injection.Methods Measurement of mouse ear swelling caused by dimethylbenzene ,of rat posterior peri-metatarsal swelling in Freund's complete adjuvant arthritis and of relative weight of rat spleen,thymus,adrenal gland,iliac lymph nodes to the whole body,to assess the anti-inflammatory effects of AA injection;observation of the analgesic effects of AA injection on acetic acid-caused mouse writhing.Results AA injection markedly inhibited acute inflammatory ear swelling following dimethylbenzene stimulation on mouse ear;therapeutic use of AA injection (4mg/kg) significantly decreased the swlling of adjuvant arthritis foot(right) and left(control) foot,s delayed allergic swelling on rat on the 5th and 8th treatment day;AA injection showed evident protective effects in adjuvant arthritis in scoring method,and markedly alleviated mouse's writhing after acetic acid stimulation.Conclusion AA injection has anti-inflammatory and analgesic effects.