Genetic analysis of integrin activation in T lymphocytes |
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| Authors: | Sirid-Aimé e Kellermann,Cheryl L. Dell,Stephen W. Hunt III,Yoji Shimizu |
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| Affiliation: | Authors' addresses;Sirid-Aimée Kellermann1*, Cheryl L. Dell2, Stephen W. Hunt III2, Yoji Shimizu1, 1Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA2Department of Molecular Sciences and Technologies, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA*Current address: Abgenix, Inc., 6701 Kaiser Dr MS 11, Fremont, CA 94555, USA. |
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| Abstract: | Summary: Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined. |
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