| 杏仁对12种抗肿瘤药物的诱变性的抑制效应 |
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| 引用本文： | 赵泽贞,温登瑰.杏仁对12种抗肿瘤药物的诱变性的抑制效应[J].癌变．畸变．突变,1992,4(6):49-50,10. |
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| 作者姓名： | 赵泽贞 温登瑰 |
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| 作者单位： | 河北省肿瘤研究所，河北省肿瘤研究所，河北省肿瘤研究所，河北省肿瘤研究所 石家庄 05001，石家庄 05001，石家庄 05001，石家庄 05001 |
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| 摘 要： | 本文报告用致突变和抗突变同步试验法对中药苦杏仁的测试结果,发现其无致突变性,而且对表阿霉素、卡铂、环己亚硝脲、甲基苄肼、塞替哌、呋喃氟脲嘧啶、丝裂霉素C(MMC)、平阳霉素、氟脲嘧啶、顺铂、阿糖胞苷、盐酸氮芥12种抗肿瘤药物的诱变性有明显的抑制作用,经原噬菌体诱导及Ames两种同步试验法,加及不加大鼠微粒体酶代谢活化系统(S_9),结果一致,提示苦杏仁可望成为肿瘤化疗药物毒副作用的拮抗剂。
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| 关 键 词： | 苦杏仁 抗突变 抗癌药 |
A STUDY ON ALMONDS INHIBITION OF MUTATION INDUCED BY 12 ANTINEOPLASTIC DRUGS |
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| Abstract: | With the aim to see whether Almod has the function of inhibiting genetic toxicity, we adopted rnutational and antimutational synchronous inductest and Ames' test to examine it's reaction towards mutagenesis induced by 12 antineoplastic drugs .The results indicated that Almond suppresses mutagenesis induced by Fluo-rouracilum, Ftorafurum,Cytarabinum, Mitomycinum Procarbazinum, Cis. platinum diamine dichloridum, Thiophosphoramide, Lomustinum, Mustinae hydrochloridum, Pharmorubicin, Carboplatinum and Bleomycunum.It Seemed that Almond can be prescribed to clinical cancer patients while receiving chemotherapy to eliminate the drug's side genotoxicity. |
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| Keywords: | Almond Antineoplastic drugs Antimutagenesis |
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