| 蒲黄及其提取物对花生四烯酸诱导血小板聚集功能的影响 |
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| 引用本文： | 刘凤鸣,石山,李增晞,冯欣,张晔.蒲黄及其提取物对花生四烯酸诱导血小板聚集功能的影响[J].中国药理学通报,1990(5). |
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| 作者姓名： | 刘凤鸣 石山 李增晞 冯欣 张晔 |
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| 作者单位： | 包头医学院心血管研究室，包头医学院心血管研究室，包头医学院心血管研究室，包头医学院心血管研究室，包头医学院心血管研究室 包头 014010，包头 014010，包头 014010，包头 014010，包头 014010 |
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| 摘 要： | 蒲黄及提取物总黄酮、有机酸、多糖对花生四烯酸诱导兔体内外血小板聚集功能具有明显的抑制作用,抑制最大聚集%的作用强度依次为:总黄酮>多糖>煎液>有机酸;抑制聚集坡度的作用强度为:总黄酮>煎液>多糖>有机酸;说明黄酮类物质可能是蒲黄抗血小板聚集的主要有效成分,同时表明这些药物对血小板最大聚集%和坡度的作用是有差别的。
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| 关 键 词： | 蒲黄 黄酮 有机酸 多糖 血小板聚集 聚集坡度 花生四烯酸 |
EFFECTS OF TYPHA ANGUSTIFOCIA L AND ITS EXTRACTS ON ARACHIDONIC ACID INDUCED PLATELET AGGREGATION IN RABBITS |
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| Liu Fengming,Shi Shan,Li Zengxi et al.EFFECTS OF TYPHA ANGUSTIFOCIA L AND ITS EXTRACTS ON ARACHIDONIC ACID INDUCED PLATELET AGGREGATION IN RABBITS[J].Chinese Pharmacological Bulletin,1990(5). |
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| Authors: | Liu Fengming Shi Shan Li Zengxi |
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| Abstract: | Typha angustifocia L(TA ) and its extracts: total flavones ( FT ) , organic acids ( OT ) , and poly saccharide ( PT ) inhibited platelet-aggregation induced by arachidonic acid in rabbits significantly and dose-dependend in vitro. The IC50-m of TA, FT, OT and PT for maximum aggregation % was 9.3, 3.0, 12.1, and 6.5g/L PRP and IC50-s for aggregating slope was 10.8, 4.3, 17.7 and 15.3 g/L PRP respectively. The ratio of IC50-m/IC50-s was TA 1 : 1.2, FT 1 : 1.4, OT 1 : 1.5, and PT I : 2.4 respectively. FT and OT also showed inhibition to platelet aggregation exvivo. The results proved that flavones may be the principal effective ingredient of Typha angustifocia L on platelet aggregation and responsible for the difference the drug effects on maximum aggregation % and aggregation slope between. |
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| Keywords: | Typha angustifocia L Flavone Organic acid Polysaccharide Platelet aggregation Platelet aggregation slope Arachidonic acid |
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