Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans |
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Authors: | Deqing Wu James R Cypser Anatoli I Yashin Thomas E Johnson |
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Institution: | aInstitute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, CO 80309, USA;bDepartment of Integrative Physiology, University of Colorado at Boulder, Box 354, Boulder, CO 80309, USA;cCenter for Population Health and Aging, Duke University, Box 90408002 Trent Hall, Durham, NC 27708, USA |
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Abstract: | Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging. |
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Keywords: | Heat-shock Gompertz Mortality Caenorhabditis elegans Hormesis Caloric restriction Stress Stressors Initial mortality Demography |
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