| 4,4-二(二乙氧膦酰)-丁酸的合成 |
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| 引用本文： | 吴林艳,李佩杰,吴勇. 4,4-二(二乙氧膦酰)-丁酸的合成[J]. 华西药学杂志, 2002, 17(5): 348-349 |
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| 作者姓名： | 吴林艳 李佩杰 吴勇 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目 (批准号 :39970 86 9) |
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| 摘 要： | 目的：探讨4，4-二（二乙氧膦酰）-丁酸的合成研究。方法：以亚甲基二膦酸四乙酯为原料，经5步反应合成目标物。结果：总收率为64％。结论：该方法操作简单易行，是合成目标化合物的较好方法。
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| 关 键 词： | 4 4－二（二乙氧膦酰）－丁酸 合成方法 骨靶向 |
| 文章编号： | 1006-0103(2002)05-0348-02 |
| 修稿时间： | 2002-03-01 |
SYNTHESIS OF 4,4-BIS(DIETHOXYPHOSPHORYL) BUTANOIC ACID |
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| WU Lin-yan,LI Pei-jie,WU Yong West China School of Pharmacy,Sichuan University,Chengdu ,China. SYNTHESIS OF 4,4-BIS(DIETHOXYPHOSPHORYL) BUTANOIC ACID[J]. West China Journal of Pharmaceutical Sciences, 2002, 17(5): 348-349 |
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| Authors: | WU Lin-yan LI Pei-jie WU Yong West China School of Pharmacy Sichuan University Chengdu China |
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| Affiliation: | WU Lin-yan,LI Pei-jie,WU Yong West China School of Pharmacy,Sichuan University,Chengdu 610041,China |
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| Abstract: | OBJECTIVE To study the synthetic method of 4,4-bis(diethoxyphosphoryl) butanoic acid.METHODS The title compound was synthesized via five steps starting from tetraethyl methylene diphosphorate.RESULTS The overall yield of the method is 64%, and the process is simple.CONCLUSION The method is an efficient method for synthesis of the compound. |
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| Keywords: | Bis(diethoxyphosphoryl) butanoic acid Synthetic method Bone-targeted |
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