| 老年冠心病患者外周血粘附细胞产生白细胞介素1的研究 |
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| 引用本文： | 周荣斌,崔致贤,金伯泉.老年冠心病患者外周血粘附细胞产生白细胞介素1的研究[J].中国急救医学,2001,21(1):10-11. |
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| 作者姓名： | 周荣斌 崔致贤 金伯泉 |
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| 作者单位： | 1. 北京军区总医院,
2. 第四军医大学西京医院 |
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| 摘 要： | 目的 探讨老年冠心病人外周血粘附细胞产生白细胞介素1(IL-1)的变化及其与动脉粥样硬化的关系。方法 采用细胞培养生物学活性检测及放免分析的方法测定冠心病人外周血粘附细胞产生IL-1的活性。结果 老年冠心病人外周血粘附细胞产生IL-1的活性明显高于正常老年人。结论 老年冠心病人IL-1活性的增高可通过对血管平滑肌细胞、内皮细胞、补体以及在炎症损伤中的作用对动脉粥样硬化的发生产生重要影响。
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| 关 键 词： | 冠心病 免疫 白细胞介素-1 粘附细胞 |
| 文章编号： | 1002-1949(2001)01-0010-02 |
| 修稿时间： | 2000年7月25日 |
Studies on Interleukin-1 activities of peripheral blood mononuclear adhered cells in patients with coronary heart disease |
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| ZHOU Rong-bin,CUI Zhi-x ian,JIN Bo-quan.Studies on Interleukin-1 activities of peripheral blood mononuclear adhered cells in patients with coronary heart disease[J].Chinese Journal of Critical Care Medicine,2001,21(1):10-11. |
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| Authors: | ZHOU Rong-bin CUI Zhi-x ian JIN Bo-quan |
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| Institution: | ZHOU Rong-bin 1,CUI Zhi-xian 2,JIN Bo-quan 2 1 Beijing Military Region General Hospital of PLA,Beijing 100700,China [ |
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| Abstract: | Objective To study the roles of cell immune reaction,especially the concentration changes of interleukin-1 to pathogenesis of elderly coronary heart disease(CHD).Methods Quantitative measuring the concentration of interleukin-1 which produced by peripheral blood mononuclear adhered cells of elderly CHD patients by bioactive measuring method.Results The activity of IL-1 was significantly increased in patients with CHD than that in normal controls.Conclusions The activity of IL-1 in patients with CHD was significantly increased,this may play an important part in pathogenesis of atherosclerosis by the role of vascular smooth cell,epithelia cell,complements and inflammation reactions. |
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| Keywords: | Coronary heart disease Immunity Interleukin-1 Peripheral blood mononuclear adhered cellx |
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