| 盐酸氯丙嗪控释片的制备与体内外释药 |
| |
| 引用本文： | 侯惠民,顾卫国,张美森,王雅珍,施丽西,高松盛,彭定才.盐酸氯丙嗪控释片的制备与体内外释药[J].中国医药工业杂志,1988(8). |
| |
| 作者姓名： | 侯惠民 顾卫国 张美森 王雅珍 施丽西 高松盛 彭定才 |
| |
| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海黄河制药厂，上海黄河制药厂 |
| |
| 摘 要： | 盐酸氯丙嗪控释片由醋酸纤维素微孔膜包衣制得。该片在体外具有恒定的释药速率,且可随包衣膜的厚度不同而改变。家犬的单剂量及连续给药试验表明,本控释片能在24h 内维持恒定的血药浓度,对比一般片剂,两者的生物利用度相接近。
|
| 关 键 词： | 盐酸氯丙嗪 控释 醋酸纤维素 包衣片 |
PREPARATION AND BIOAVAILABILITY OF CONTROLLED RELEASE TABLETS OF CHLORPROMAZINE HYDROCHLORIDE |
| |
| Authors: | HOU Hui-Min GU Wei-Guo ZHANG Mei-Sen WANG Ya-Zhen SHI Li-Xi GAO Song-Shenga PENG Ding-Caia |
| |
| Institution: | HOU Hui-Min~* GU Wei-Guo ZHANG Mei-Sen WANG Ya-Zhen SHI Li-Xi GAO Song-Sheng~a PENG Ding-Cai~a |
| |
| Abstract: | Controlled release tablets of chlorpromazine hydrochloride(CPM)were prepared by coating method with cellulose acetate.CPM was released bydiffusion through the coating film and the release rate was influenced by thethickness of the coating film.Animal experiments in dogs suggested that thetablets with constant release rate could maintain steady blood concentrationduring 24h,and the bioavailability was comparable to conventional ones. |
| |
| Keywords: | chlorpromazine hydrochloride controlled release cellulose acetate coated tablets |
| 本文献已被 CNKI 等数据库收录！ |
