Effect of smoking on inflammatory bowel disease: Is it disease or organ specific? |
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作者姓名: | Karban A Eliakim R |
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作者单位: | Department of Medicine C Rambam Health Care Campus Bruce Rappaport School of Medicine,Technion-Israel Institute of Technology,Haifa,Israel,Department of Gastroenterology Rambam Health Care Campus,Bruce Rappaport School of Medicine,Technion-Israel Institute of Technology,Haifa,Israel |
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摘 要: | Smoking is an important environmental factor in inflammatory bowel disease (IBD) with differing effects in ulcerative colitis (UC) and Crohn's disease (CD). Never smoking and formerly smoking increase the risk of UC, whereas smoking exacerbates the course of CD. The potential mechanisms involved in this dual relationship are yet unknown. A reasonable assumption is that smoking has different effects on the small and large intestine. This assumption is based on animal and human studies that show that the effects of smoking/nicotine on CD and UC depend on the site of inflammation and not on the type of disease.
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关 键 词: | 吸烟 炎症性肠病 溃疡性大肠炎 小肠 结肠 |
收稿时间: | 2006 Mar 7 |
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