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miRNA对肿瘤生物学特性的影响
引用本文:徐小方.miRNA对肿瘤生物学特性的影响[J].国际肿瘤学杂志,2008,35(10):747-750.
作者姓名:徐小方
作者单位:第四军医大学口腔医院口腔生物学教研室,西安,710032
摘    要:研究显示miRNA与肿瘤发生形成过程及其恶性生物学行为密切相关,作为一种调节分子可能参与了肿瘤的发生以及肿瘤细胞的增殖、分化、细胞凋亡、侵袭和转移及肿瘤耐药等的调节.miRNA靶标及其作用机制的深入研究可为解开肿瘤的发生发展机制及肿瘤治疗策略提供新的思路.

关 键 词:微RNAs  肿瘤  基因表达调控  肿瘤形成过程  抗药性  肿瘤

Effect of miRNA on biological characteristics of tumor
XU Xiao-fang.Effect of miRNA on biological characteristics of tumor[J].Journal of International Oncology,2008,35(10):747-750.
Authors:XU Xiao-fang
Abstract:Studies indicate that miRNAs correlate closely with tumorigenesis and tumor biological be-haviors, and play a significant role as a kind of regnlating factor in tumorigenesis, tumor cells proliferation, dif-ferentiation, apoptosis, invasion and metastasis, as well as in drug resistance of tumors. Further study of the targets and mechanisms of miRNA may be helpful to recognize the characterization of tumor biology and etiolo-gy, and bring new strategies for tumor therapy.
Keywords:MicroRNAs  Neoplasms  Gene expression regulation  Neoplastic processes  Drug resist-ance  neoplasm
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