Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients |
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| Authors: | Sai Kimie Saito Yoshiro Sakamoto Hiromi Shirao Kuniaki Kurose Koichi Saeki Mayumi Ozawa Shogo Kaniwa Nahoko Hirohashi Setsuo Saijo Nagahiro Sawada Jun-ichi Yoshida Teruhiko |
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| Affiliation: | Division of Biosignaling, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. sai@nihs.go.jp |
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| Abstract: | Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant *6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan monotherapy (p=0.012). This study further clarifies the clinical importance of *6 in irinotecan therapy in East Asians. |
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| Keywords: | UGT1A1 Pharmacogenetics Irinotecan SN-38 |
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