| 抗霉菌药1-[β-(对硝基苯氧基)-2,4-二氯苯乙基]咪唑硝酸盐的合成 |
| |
| 引用本文： | 刘少诚,徐春,伊东辉,段平.抗霉菌药1-[β-(对硝基苯氧基)-2,4-二氯苯乙基]咪唑硝酸盐的合成[J].沈阳药科大学学报,1986(4). |
| |
| 作者姓名： | 刘少诚 徐春 伊东辉 段平 |
| |
| 作者单位： | 沈阳药学院药物化学教研室，沈阳药学院药物化学教研室，沈阳药学院药物化学教研室，沈阳药学院药物化学教研室 制药48期毕业生，药学48期毕业生 |
| |
| 摘 要： | 合成抗霉菌药1-β-(对-硝基苯氧基)-2,4-二氯苯乙基]咪唑时,制备2',4'-二氯-2-(1-咪唑基)苯乙酮(Ⅲ),用过量咪唑作缩合剂效果较好(过量咪唑可以回收)。α-(2,4-二氯苯基)咪唑-1-乙醇和对-硝基氯苯缩合时,使用极性和非极性溶剂并使用适当触媒优于用四氢呋喃。
|
| 关 键 词： | 抗霉菌剂 1-〔β-(对-硝基苯氧基)-2 4-二氯苯乙基〕咪唑硝酸盐 |
THE SYNTHESIS OF ANTIFUNGAL AGENT 1-[β-(P-NITROPHENOXY)-2,4-DICHLOROPHENETHYL]IMIDAZOLE NITRATE |
| |
| Liu Shaocheng Xu Chun Yi Donghui Duan Ping.THE SYNTHESIS OF ANTIFUNGAL AGENT 1-[β-(P-NITROPHENOXY)-2,4-DICHLOROPHENETHYL]IMIDAZOLE NITRATE[J].Journal of Shenyang Pharmaceutical University,1986(4). |
| |
| Authors: | Liu Shaocheng Xu Chun Yi Donghui Duan Ping |
| |
| Institution: | Liu Shaocheng Xu Chun Yi Donghui Duan Ping Department of Pharmaceutical Chemistry |
| |
| Abstract: | We synthesized the title compound with methods different from those reported in the reference.In preparation of 2',4'-dichloro-2-(imidazolyl) acetophenone(Ⅲ)excess imidazole was used as condensating agent,satisfactory result had been obtained(excess imidazole may be recovered).In condensation of α-(2,4-dichlorophenyl)imidazole-1-ethanol and p-nitrochlorobenzene polar and nonpolar solvents were used and proper catalyst was used,which was superior to tetrafurane. |
| |
| Keywords: | Antifungal agent 1-[β-(p-Nitrophenoxy)-2 4-dichlorophenethyl]imidazole nitrate |
| 本文献已被 CNKI 等数据库收录！ |
