Specific chromosomal imbalances as detected by array CGH in ependymomas in association with tumor location,histological subtype and grade |
| |
Authors: | Audrey Rousseau Ahmed Idbaih François Ducray Emmanuelle Crinière Michèle Fèvre-Montange Anne Jouvet Jean-Yves Delattre |
| |
Institution: | 1.UPMC – INSERM U711. Neuro-Oncologie expérimentale,Paris,France;2.Service de Neuropathologie. H?pital de la Pitié-Salpêtrière. Boulevard de l’H?pital,Paris,France;3.INSERM U842. Neuro-oncologie et Neuro-inflammation. Faculté de Médecine RTH Laennec,Lyon,France;4.Service de Neuropathologie Est, H?pital Neurologique,Lyon,France |
| |
Abstract: | Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of
histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in
the pathogenesis of ependymoma are yet to be defined. The main objective of the present study was to identify specific patterns
of chromosomal aberrations that correlate with tumor location, histological subtype and grade. Forty-five ependymoma samples
were analyzed by 1-megabase resolution array comparative genomic hybridization (CGH). Association between clinical or histopathological
parameters and the genomic alterations identified was evaluated. The most frequently detected chromosome (chr) abnormalities
were gain of chr 7, 9, 12 and 15 and loss of chr 22. Co-occurrence of those five alterations characterized spinal ependymomas
(P = 0.01). Myxopapillary ependymomas displayed a specific genomic profile defined by concurrent gain of chr 5, 7, 9, 16 and
18 (P = 0.0007). Overall, the number of chromosomal abnormalities detected was inversely correlated with the malignancy grade.
Gain of chr 1q correlated with intracranial high-grade tumors (P = 0.002). Loss of chr 6q was mainly observed in infratentorial (P = 0.02) and World Health Organization (WHO) grade III (P = 0.04) lesions. Chr 10q loss was associated with high-grade ependymomas (P = 0.01). The +7/+9/+12/+15/−22 genomic profile is significantly associated with WHO grade II spinal ependymomas, whereas
the +5/+7/+9/+16/+18 genomic pattern is specific of myxopapillary ependymomas. Identification of specific genomic imbalances
at a given tumor location suggests that ependymomas from different central nervous system (CNS) regions represent genetically
distinct diseases. Detecting genomic alterations associated with aggressive biological behavior may help stratify patients
in high- and low-risk disease. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|