Vergleichende Morphologie des lymphoepithelialen Karzinoms Primärtumor — Metastase — Xenotransplantat |
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Authors: | W Arnold F Huth J Lindenberger K H Vosteen |
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Institution: | (1) Hals-, Nasen- und Ohrenklinik der Universität Düsseldorf, Moorenstraße 5, D-4000 Düsseldorf, Bundesrepublik Deutschland;(2) Pathologisches Institut der Universität Düsseldorf, Moorenstraße 5, D-4000 Düsseldorf, Bundesrepublik Deutschland |
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Abstract: | Summary Tissue of lymphoepithelial tumor metastasis was transplanted subcutaneously to thymus-aplastic nude mice. After 75 days a pea-size tumor was developing which again was transplanted to further murine passages. During the second passage the tumor was growing faster and material was taken for light and electron microscopy. The results were compaired with the datas obtained from the primary nasopharyngeal carcinoma and metastasis. The tumor cells of the metastasis and of the xenograft showed all morphological criteria of a non-ceratinizing squamous epithelial carcinoma of undifferentiated type. The ultrastructural criteria of the human NPC-tumor cells were all present including cytoplasmic deposits of Corona viruses and Herpes virus-like particles within the nuclei and the cytoplasm.Für hervorragende Assistenz danken wir Frl. S. Linnenkohl und Frau U. Kostka. |
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Keywords: | Lymphoepithelial carcinoma Xenograft Morphology Virus-like structures Corona viruses |
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