刹毒草口服液的药理作用研究

目的:研究刹毒草口服液对小鼠的药理作用。方法:用小鼠分别进行爬杆实验、炭粒廓清实验、耳肿胀实验和墨汁推进实验,观察刹毒草口服液对小鼠的抗疲劳作用、非特异性免疫功能的影响、抗炎作用和抗腹泻作用。结果:刹毒草口服液能显著延长小鼠爬杆时间,有较好的抗疲劳作用;高剂量刹毒草口服液能显著提高小鼠对惰性炭粒的吞噬指数及吞噬活性,可提高小鼠免疫功能;刹毒草口服液3个剂量组均对二甲苯致小鼠耳炎症有较好的抑制作用,且能显著降低墨汁推进的速率,有较好的抗腹泻作用。结论:刹毒草口服液具有一定抗疲劳、抗炎、提高非特异性免疫功能和抗腹泻作用。

Pharmacological Effect of Shaducao Oral Succus

OBJECTIVE:To study the pharmacological action of Shaducao oral succus in mice.METHODS:Pole-climbing test,charcoal clearance test,ear-swelling test,ink-propelling test were conducted respectively to observe the antifatigue action of Shaducao oral succus,and its effect on nonspecific immunity,anti-inflammatory and anti-diarrhea effects on mice. RESULTS: Shaducao oral succus markedly prolonged the duration of mice in climbing pole,and it also showed remarkable antifatigue effect. High dose of Shaducao oral succus significantly enhanced mice's charcoal clearance coefficient and clearance capacity index and enhanced mice's immune function.At high,middle and low doses,Shaducao oral succus markedly ameliorated dimethyl benzene-induced otitis,significantly lowered the ink-propelling speed,and satisfactorily relieved diarrhea. CONCLUSION: Shaducao oral succus was proved to be of certain antifatigue,anti-inflammatory and anti-diarrhea effects meanwhile it could enhance the nonspecific immunity of mice.