| 子宫腺肌症雌激素受体、孕激素受体与bcl-2的表达 |
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| 引用本文： | 廖谦和,胡树红,陈利琼,吴文珍,阮荣和,蔡宇清,夏康. 子宫腺肌症雌激素受体、孕激素受体与bcl-2的表达[J]. 临床与实验病理学杂志, 2006, 22(6): 663-665 |
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| 作者姓名： | 廖谦和 胡树红 陈利琼 吴文珍 阮荣和 蔡宇清 夏康 |
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| 作者单位： | 温州医学院附属第三医院病理科,瑞安,325200;温州医学院附属第三医院妇产科,瑞安,325200 |
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| 基金项目： | 浙江省温州市科技局医药卫生科技计划项目（Y2005A179） |
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| 摘 要： | 目的 探讨雌激素受体（ER）、孕激素受体（PR）和bcl-2在子宫腺肌症中异位和在位内膜的表达及意义。方法 用免疫组化EnVision法检测40例子宫腺肌症在位子宫内膜和肌间异位内膜ER、PR和bcl-2的表达情况。结果 在位和异位子宫内膜组织中均有ER、PR和bcl-2的阳性表达。其中腺上皮阳性表达率高于间质（P〈0．05），且异位内膜的腺上皮bcl-2阳性表达率高于在位组织（P〈0．05）；ER和PR的表达两者差异无显著性（P〉0．05）。异位内膜腺体ER、PR与bcl-2表达具有相关性（P〈0．01）。结论 子宫腺肌症异位和在位子宫内膜组织中均有ER、PR和bcl-2的阳性表达，可能与子宫腺肌症的发生、发展有关。
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| 关 键 词： | 子宫疾病 子宫腺肌症 雌激素受体 孕激素受体 bcl-2 免疫组织化学 |
| 文章编号： | 1001-7399(2006)06-0663-03 |
| 收稿时间： | 2006-06-26 |
| 修稿时间： | 2006-09-18 |
Expressions of estrogen receptor, progesterone receptor and bcl-2 in adenomyosis uterus |
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| LIAO Qian-he,HU Shu-hong,CHEN Li-qiong,WU Wen-zhen,RUAN Rong-he,CAI Yu-qing,XIA Kang. Expressions of estrogen receptor, progesterone receptor and bcl-2 in adenomyosis uterus[J]. Chinese Journal of Clinical and Experimental Pathology, 2006, 22(6): 663-665 |
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| Authors: | LIAO Qian-he HU Shu-hong CHEN Li-qiong WU Wen-zhen RUAN Rong-he CAI Yu-qing XIA Kang |
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| Affiliation: | 1 Department of Pathology; 2 Department of Obstetrics and Gynecology, Third Affiliated Hospital, Wenzhou Medical College, Ruian 325200, China |
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| Abstract: | Purpose To investigate the expressions of ER, PR and bcl-2 in the pathogenesis of adenomyosis uterus. Methods The expressions of ER, PR and bcl-2 in 40 cases of adenomyosis uterus were detected by immunohistochemical EnVision method. Results Both the eutopic and ectopic endometrium in 40 cases showed positive for ER, PR and bcl-2 (P>0.05). The strong positive rate in the eutopic endometrium was significantly higher than that in the stroma cells (P<0.05). The expression of bcl-2 increased significantly in ectopic endometrium was slightly than those in eutopic endometrium (P<0.05). The expression of ER and PR had a positive correlation with the expression of bcl-2 (P<0.01). Conclusions ER, PR and bcl-2 may play an important roles in promoting the development of adenomyosis. |
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| Keywords: | uterine diseases adenomyosis estrogen receptor progesterone receptor bcl-2 protein immunohistochemistry |
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