| 一氧化氮对实验性肾炎中肾小球花生四烯酸产物的影响 |
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| 引用本文： | 吴升华,张淑英,林致华,ELias A.Lianos.一氧化氮对实验性肾炎中肾小球花生四烯酸产物的影响[J].肾脏病与透析肾移植杂志,1999,8(2):116-118. |
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| 作者姓名： | 吴升华 张淑英 林致华 ELias A.Lianos |
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| 作者单位： | 1. 南京医科大学第一附属医院儿科,南京,210029
2. 美国威斯康辛医学院肾科 |
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| 摘 要： | 目的：探讨一氧化氮（ＮＯ）在实验性肾小球肾为中对肾小球花生四烯酸（ＡＡ）产物合成的调节作用。方法：制备大鼠加速性肾毒性肾炎（ＮＳＮ）模型，应用市郊和液相层析及放免法测定肾小球合成的前列腺素（ＰＧ）Ｅ２、６－酮－ＰＧＦ１α、血栓素（ＴＸ）Ｂ２、白三烯（ＬＴ）Ｂ４、ＬＴＣ４、５－羟二十碳四烯酸（５－ＨＥＴＥ）、１２－ＨＥＴＥ、１５－ＨＥＴＥ。对ＮＳＮ大鼠应用诱生型ＮＯ合成酶（ｉＮＯＳ）抑制剂Ｌ－ＮＩＬ
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| 关 键 词： | 一氧化氮 花生四烯酸产物 肾小球肾炎 病理学 |
THE EFFECTS OF NITRIC OXIDE ON GLOMERULAR SYNTHESIS OF EICOSANOIDS IN NEPHROTOXIC SERUM NEPHRITIS IN RATS |
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| Wu Shenghua,Zhang Shuying,Lin Zhihua,ELias A.Lianos.THE EFFECTS OF NITRIC OXIDE ON GLOMERULAR SYNTHESIS OF EICOSANOIDS IN NEPHROTOXIC SERUM NEPHRITIS IN RATS[J].Chinese Journal of Nephrology, Dialysis & Transplantation,1999,8(2):116-118. |
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| Authors: | Wu Shenghua Zhang Shuying Lin Zhihua ELias ALianos |
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| Abstract: | OBJECTIVE To investigate the effect of nitric oxide(NO)on glomerular synthesis of eicosanoids in accelerated nephrotoxic serum nephritis(NSN)in rats. METHODOLOGY Glomerular synthesis of prostaglandin(PG)E2,6 keto PGF12,thromboxane(TX)B2,leukotries(LT)B4,LTC4,5 hydroxyeicosatetraenoic acid(5 HETE),12 HETE,15 HETE were determined with high pressure liquid chromatography and radioimmunoassay.Rats of NSN were treated with L NIL,an inhibitor of inducible nitric oxide synthase(iNOS). RESULTS Glomerular synthesis of PGE2,6 keto PGF12,TXB2,LTB4,5 HETE and 15 HETE1 were enhanced in rats of NSN except LTC4.The enhanced glomerular synthesis of the eicosanoids were inhibited by the treatment with L NIL. CONCLUSION iNOS derived NO stimulates glomerular activity of cyclooxygenase,5 and 15 lipoxygenases,promotes the syntheses of PEG2,PGI2,LTB4,5 HETE and 15 HETE that might be involved in the pathogenesis of NSN. |
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| Keywords: | nitric oxide eicosanoid nephritis |
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