| D-Limonene对小鼠移植瘤生长及淋巴管生成的影响 |
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| 引用本文： | 杨慧科,李玉兰,刘慧冬,李晓冬,杨树才,龚春琳,赵玲辉.D-Limonene对小鼠移植瘤生长及淋巴管生成的影响[J].中国临床解剖学杂志,2007,25(1):57-59. |
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| 作者姓名： | 杨慧科 李玉兰 刘慧冬 李晓冬 杨树才 龚春琳 赵玲辉 |
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| 作者单位： | 哈尔滨医科大学基础医学院解剖教研室,哈尔滨,150086 |
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| 基金项目： | 黑龙江省科技厅科技攻关项目;黑龙江省卫生厅科学技术课题;黑龙江省自然科学基金 |
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| 摘 要： | 目的:观察右旋柠烯对小鼠移植瘤生长及淋巴管生成的影响,并探讨其作用机制。方法:皮下注射肉瘤(S180)腹水型瘤株构建小鼠移植瘤模型,给予D-Lim onene干预,免疫组化染色观察瘤细胞V EG F-C表达,LY V E-1标记淋巴管,观察其分布。结果:对照组瘤细胞V EG F-C表达较强,瘤周边部淋巴管较多,有淋巴结、肺转移。用药组瘤细胞V EG F-C表达较弱;瘤周边部淋巴管较少,未见淋巴结、肺转移。结论:D-Lim onene有抑制移植瘤内瘤细胞V EG F-C表达和淋巴管生成的作用,有可能降低肿瘤的淋巴道转移。
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| 关 键 词： | 右旋柠烯 移植瘤 淋巴管生成 |
| 文章编号： | 1001-165X(2007)01-057-03 |
| 修稿时间： | 2006年8月31日 |
The effects of the D-limonene on the growth of transplantation tumors and lymphangiogenesis in mouse |
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| YANG Hui-ke,LI Yu-lan,LIU Hui-dong,et al..The effects of the D-limonene on the growth of transplantation tumors and lymphangiogenesis in mouse[J].Chinese Journal of Clinical Anatomy,2007,25(1):57-59. |
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| Authors: | YANG Hui-ke LI Yu-lan LIU Hui-dong |
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| Institution: | YANG Hui-ke,LI Yu-lan,LIU Hui-dong,et al. Department of Anatomy,Harbin Medical University,Harbin 150086,China |
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| Abstract: | Objective:To explore the effects of D-limonene on the growth and lymphangiogenesis of transplantation tumor in mouse. Methods: The models of mice with transplantation tumor were established by inoculating S180 cells under skin. The present study, using the immunohistochemical method, investigated the growth of tumor by observing the expression of VEGF-C and the distribution of lymphatic vessels by examining the LYVE-1 mediated by D-Limonene. Results: D-limonene induced a decreased expression of VEGF-C in tumor cells and distribution of lymphatic vessels in periphery of tumor. Furthermore, metastasis was absent in D-limonene group compared with its presence in control group.Conclusions: D-limonene inhibits significantly the expression of VEGF-C, the lymphangiogenesis and metastasis in tumor tissue. |
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| Keywords: | LYVE-1 |
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