脑弥漫性轴索损伤后凝血功能的改变及亚低温治疗的影响

目的探讨亚低温治疗对脑弥漫性轴索损伤(DAI)后凝血功能改变的影响。方法对分别采用亚低温治疗和常温治疗的47例DAI患者的临床资料进行对比分析。结果DAI患者伤后血小板计数、纤维蛋白原定量及D-二聚体含量均显著高于正常对照组(P<0.05)。经亚低温治疗后DAI患者的血小板计数、纤维蛋白原定量明显降低,其水平接近正常对照组(P>0.05),D-二聚体也较治疗前显著降低(P<0.05),但仍高于正常对照组(P<0.05)。常温治疗组DAI患者血小板计数,D-二聚体含量仍显著高于正常对照组(P<0.05),纤维蛋白原定量却显著低于正常对照组(P<0.05)。结论经亚低温治疗可以降低DAI后升高的血小板计数、纤维蛋白原定量及D-二聚体含量。

Impact of Sub-hypothermia Therapy on Coagulation Function in Diffuse Axonal Injury Sufferers

Objective:To discuss tile impact of sub-hypothermia therapy on coagulation function in diffuse axonal injury sufferers. Methods: 47 qualified DAI cases are divided into two groups: sub-hypothermia therapy group and common temperature therapy group,which clincal materials are analysed. Results: The platelet count,fibrinogen and D-dimer are increased significantly in Diffuse Axonal Injury Sufferers. There is insignificant difference (P>0.05) between sub-hypothermia therapy group and common compare group on expression of the platelet count and fibrinogen,the D-dimer is also decreased significantly (P<0.05) by sub-hypothermia therapy. The platelet count and D-dimer are increased significantly (P<0.05) in comparison to that of common compare group ,but fibrinogen is decreased significantly (P<0.05) .Conclusions: The platelet count,fibrinogen and D-dimer are decreased significantly by sub-hypothermia therapy.