Arterial windkessel parameter estimation: A new time-domain method |
| |
Authors: | Youngtack Shim Ares Pasipoularides Craig A Straley Thomas G Hampton Pablo F Soto Clarence H Owen James W Davis Donald D Glower |
| |
Institution: | (1) Department of Biomedical Engineering, Duke University, Durham, NC;(2) Department of Surgery, Duke University Medical Center, Durham, NC;(3) Departments of Biomedical Engineering and Surgery, Duke University, Room 136, Engineering Building, 27706 Durham, NC |
| |
Abstract: | We developed and validated a new, more accurate, and easily applied method for calculating the parameters of the three-element
Windkessel to quantitate arterial properties and to investigate ventriculoarterial coupling. This method is based on integrating
the governing differential equation of the three-element Windkessel and solving for arterial compliance. It accounts for the
interaction between characteristic impedance and compliance, an important phenomenon that has been ignored by previously implemented
methods. The new integral method was compared with four previously published methods as well as a new independent linear least-squares
analysis, using ascending aortic micromanometric and volumetric flow measurements from eight dogs. The parameters calculated
by the new integral method were found to be significantly different from those obtained by the previous methods but did not
differ significantly from maximum likelihood estimators obtained by a linear leastsquares approach. To assess the accuracy
of parameter estimation, pressure and flow waveforms were reconstructed in the time domain by numerically solving the governing
differential equation of the three-element Windkessel model. Standard deviations of reconstructed waveforms from the experimental
ensemble-averaged waveforms, which solely reflect the relative accuracy of the Windkessel parameters given by the various
methods, were calculated. The new integral method invariably yielded the smallest error. These results demonstrate the improved
accuracy of our new integral method in estimating arterial parameters of the three-element Windkessel. |
| |
Keywords: | Windkessel model Total arterial compliance Integral method Waveform reconstruction |
本文献已被 SpringerLink 等数据库收录! |
|