| 乳腺癌与微卫星不稳定性的相关研究 |
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| 引用本文： | 刘国辉,姚永华,王权,所剑. 乳腺癌与微卫星不稳定性的相关研究[J]. 中华内分泌外科杂志, 2011, 5(3): 165-166,178. DOI: 10.3760/cma.j.issn.1674-6090.2011.03.007 |
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| 作者姓名： | 刘国辉 姚永华 王权 所剑 |
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| 作者单位： | 吉林大学第一医院普外科,长春,130021 |
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| 摘 要： | 目的 探索乳腺癌微卫星不稳定性(MSI)与临床特征的相关性.方法 收集60例乳腺癌组织标本,选择5个微卫星多态性标记(位点),DNA的提取,PCR扩增,电泳,EB显色后进行MSI分析.结果 乳腺癌MSI发生率为33.3%,正常乳腺组织MSI发生率为0,乳腺癌MSI与分化程度有关.结论 MSI是乳腺癌发生的早期分子生物学...
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| 关 键 词： | 乳腺癌 微卫星不稳定性 |
Correlation between breast cancer and microsatellite instability |
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| LIU-hui,YAO Yong-hua,WANG Quan,SUO Jian. Correlation between breast cancer and microsatellite instability[J]. Chinese Journal of Endocrine Surgery, 2011, 5(3): 165-166,178. DOI: 10.3760/cma.j.issn.1674-6090.2011.03.007 |
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| Authors: | LIU-hui YAO Yong-hua WANG Quan SUO Jian |
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| Abstract: | Objective To investigate the correlation between clinical features of breast cancer and microsatellite instability(MSI).Methods 60 samples of breast cancer were eollected and 5 microsatellite polymorphism loci were selected.MSI analysis Was made after DNA isolation,PCR amplification,electrophoresis and EB staining.Results The rate of MSI was 33.3%in breast cancer and 0%in normal breast tissues.MSI in breast cancer was associated with carcinoma differentiation degree.Conclusion MSI is an early event during breast carcinogenesis and it plays an important role in estimation of malignant degree. |
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| Keywords: | Breast cancer Microsatellite instability |
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