赛尼哌诱导治疗对肝移植相关性肾衰的保护作用

目的 评估赛尼哌诱导治疗对肝移植相关性肾衰的保护作用。方法 对照研究非诱导组、诱导组手术成功率、围手术期透析时间、感染性并发症、肝，肾功能的变化。结果 诱导组的手术成功率显著高于非诱导组；急性排斥反应的发生率显著低于非诱导组；围手术期透析时间显著低于非诱导组；术后血清肌酐的下降速度明显快于非诱导组；感染性并发症发生率、转氨酶变化与非诱导组无显著差异。结论 在肝移植相关性肾衰患者中应用赛尼哌诱导治疗是安全、有效的。它可显著提高手术成功率，降低急性排斥反应的发生率。

The protective effect of daclizumab induction therapy to renal failure associated with liver transplantation

Objective To evaluate the protective effect of daclizumab induction therapy to renal failure associated with liver transplantation. Methods Clinical data of 36 cases renal failure associated with liver transplantation in the early stage after liver transplantation were analyzed retrospectively from Jan 1999 to Oct 2002. Results Success rate of daclizumab induced group was significantly higher than that of non daclizumab induced group. Morbidity of acute rejection and time needing dialysis of daclizumab induced group were significantly lower than that of non daclizumab induced group. Morbidity of infectious complications and change of amino transferase of daclizumab induced group were the same as that of non daclizumab induced group. Conclusions Daclizumab induction therapy is safe and effective for patients with renal failure associated with liver transplantation. It can significantly improve success rate of operation and decrease the morbidity of acute rejection.