| 鲨肝活性肽S-8300对小鼠急性肝损伤的保护作用 |
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| 引用本文： | 黄凤杰 李谦 吕正兵 吴梧桐. 鲨肝活性肽S-8300对小鼠急性肝损伤的保护作用[J]. 中国海洋药物, 2004, 23(1): 17-20 |
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| 作者姓名： | 黄凤杰 李谦 吕正兵 吴梧桐 |
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| 作者单位： | 中国药科大学,生物制药学院,江苏,南京,210009 |
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| 基金项目： | 国家海洋“86 3”计划基金资助项目 (2 0 0 1AA6 2 4 0 90 )，国家自然科学基金资助项目 (30 1 71 1 0 3) |
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| 摘 要： | 目的：研究鲨肝活性肽S-8300对四氯化碳(CCl4)小鼠肝损伤的保护作用。方法：采用CCl4致小鼠肝损伤，观察肝组织切片；测定生化指标，检测小鼠腹腔注射S-8300后血清谷丙转氨酶(sGPT)、血清谷草转氨酶(sGOT)和乳酸脱氢酶(LDH)活性，肝脏超氧化物歧化酶(SOD)活性与丙二醛(MDA)和谷胱甘肽(GSH)含量。结果：S-8300能明显减轻CCl4所致小鼠急性肝损伤；降低血清GPT、GOT、LDH活性及降低肝组织MDA含量，增加肝组织GSH含量和提高SOD活性。结论：鲨肝活性肽S-8300对急性肝损伤有明显的保护作用。
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| 关 键 词： | 鲨肝活性肽S-8300 四氯化碳 实验性肝损伤 |
| 文章编号： | 1002-3461(2004)01-0017-04 |
Protective effect of peptide S-8300 from shark liver on acute liver Injury in mice |
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| Abstract: | Objective To study the hepatoprotective effect of peptide S 8300 from shark liver on CCl 4 induced liver injury in mice. Methods Mice were administered ip with three doses of S 8300 for four consecutive days, followed by CCl 4 ip on d3. The activity of SGPT, SGOT, LDH, and liver SOD as well as contents of MDA and GSH in the mice liver were tested. Results S 8300 can decrease obviously the levels of SGPT, SGOT, LDH activities and liver MDA content in liver injury mice caused by CCl 4 , increase SOD activities and the content of GSH of the liver. Conclusion S 8300 has significant protective effects on experimental liver injury mice. |
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| Keywords: | Peptide S 8300 from shark liver CCl 4 experimental hepatic injury |
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