Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations |
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Authors: | Gary M. Marsh Ada O. Youk Peter Morfeld James J. Collins J. Morel Symons |
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Affiliation: | 1. Center for Occupational Biostatistics and Epidemiology and Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, United States;2. Institute for Occupational Medicine of Cologne University, Germany;3. Institute for Occupational Epidemiology and Risk Assessment of Evonik Industries, Essen, Germany;4. Epidemiology Department, 1803 Building, The Dow Chemical Company, Midland, MI 48674, United States;5. Integrated Health Services, E.I. du Pont de Nemours and Company, Newark, DE 19711, United States |
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Abstract: | Three of us (G.M., A.Y., and P.M.) performed reanalyses of the National Cancer Institute cohort study on nasopharyngeal cancer (NPC) risk among formaldehyde exposed workers (Hauptmann et al., 2004). Both reanalyses (Marsh and Youk, 2005 and Marsh et al., 2007) were published in this journal. However, the mortality follow-up performed by the NCI working group reported in two publications by Hauptmann et al., 2003 and Hauptmann et al., 2004 was later stated to be incomplete (Beane Freeman et al., 2009a and Beane Freeman et al., 2009b). This incomplete follow-up may impact the validity of the results of our reanalyses. At this time, corrected estimates for solid cancer mortality risks including NPC as reported in Hauptmann et al. (2004) have not been provided as an erratum by the authors or reported anywhere else to our knowledge. We would like to inform readers about these issues and ask for a prompt corrigendum of the 2004 publication by the NCI working group since this study has played such a prominent role in causal evaluations. |
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Keywords: | Formaldehyde Nasopharyngeal cancer Leukemia National Cancer Institute Reanalyses Incomplete mortality follow-up |
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