妊娠剧吐致基础代谢率变化的机制初探

目的探讨妊娠剧吐患者基础代谢率变化的机制.方法对妊娠剧吐患者和正常早孕妇女各30名用代谢监测仪测定静息状态的氧耗量(VO2)进行基础代谢评估,妊娠剧吐患者治疗前和治疗1w后各进行1次,两组测量前化验甲状腺激素水平.结果妊娠剧吐患者游离甲状腺素(FT4)比正常早孕妇女高,但其静息状态的VO2却减少了15.5%(P<0.01).甲状腺功能增强的妊娠剧吐患者治疗后VO2升高了11%,而甲状腺功能正常的患者治疗后VO2则无变化.结论妊娠剧吐患者静息状态的VO2明显减少,与饥饿状态相似,而与垂体-甲状腺轴活性的增加不一致.

The varying mechanism of basal metabolic rate in patients with hyperemesis gravidarum

Objective: To study the varying mechanism of basal metabolic rate in patients with hyperemesis gravidarum. Methods: Baseline evaluation was performed with the use of metabolism monitor in 30 hospitalized patients with hyperemesis gravidarum and was repeated 1 week after treatment. 30 normal pregnant women served as control subjects. Measuring plasma levels of thyroid hormones in two groups before measuring resting oxygen consumption. Results: Oxygen consumption were decreased by 15.5% (P<0.01) in patients with hyperemesis compared with control subjects. The decrease occurred despite a measurable increase of free thyroxine compared with normal pregnancy. Treatment resulted in a 11% increase in oxygen consumption in those patients with increased thyroid stimulation, but not otherwise. Conclution: Resting oxygen consumption is reduced significantly in patients with hyperemesis gravidarum that is similar with a state of starvation, but different from increases of thyroid axis activity.