置入铜丝缠绕型支架制作猪急性心肌梗死模型

目的探讨在猪冠状动脉内置入铜丝缠绕型支架制作急性心肌梗死模型的可行性,建立一种新的急性心肌梗死模型方法。方法16头中国实验用小型猪经股动脉穿刺,在前降支置入自制的铜丝缠绕型支架。1周内观察心肌肌钙蛋白I、心电图、心脏超声和冠状动脉造影。然后处死取出心脏,取目标冠状动脉和心肌,做病理学检查。结果16头小型猪均发生了心肌梗死。梗死发生后死亡2头,其中1头在术后8 h猝死,1头在术后1周冠状动脉造影复查时死于麻醉中;其余14头均存活在1周以上,完成复查,总的成功率为87.5%。结论该模型制作具有操作简单、创伤小、成本低、死亡率低、成功率高等诸多优点,可作为较好的实验研究动物模型。

Replication of Acute Myocardial Infarction by Implantating Copper-stent in Coronary Artery of Pig

Aim To explore and establish a new pig model of acute myocardial infarction. Methods Self-made copper-stents were implanted in left anterior descending coronary arteries of 16 pigs.Troponin I,echocardiography,coronary angiography,electrocardiogram and pathologic evaluation were performed to confirm AMI at one week after procedure. Results The model of myocardial infarction was successfully established in 14 of the 16 pigs and the success rate was 87.5%(14/16).One pig had sudden death at 8 hours and another died during anaesthesia at one week after procedure. Conclusion The method of establishing the pig model of myocardial infarction by implanting copper-stent in coronary artery is simple,convenient,safe and has a relatively high success rate and low mortality.