Interaction between ACTH fragments, brain opiate receptors and morphine-induced analgesia. |
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| Authors: | W H Gispen J Buitelaar V M Wiegant L Terenius D De Wied |
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| Affiliation: | 1. Division of Molecular Neurobiology, Rudolf Magnus Institute of Pharmacology and Laboratory of Physiological Chemistry, Medical Faculty, Institute of Molecular Biology, Padualaan 8, Utrecht, The Netherlands;7. Department of Medical Pharmacology, University of Uppsala, Sweden;71. Rudolf Magnus Institute for Pharmacology, Utrecht, The Netherlands |
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| Abstract: | The present study confirms that N-terminal fragments of ACTH have an affinity for rat brain opiate receptors in vitro. Such peptides, devoid of corticotrophic activity, were found to inhibit morphine-induced analgesia if they also possessed affinity for opiate receptors in vitro. The structure-activity relationship for these two parameters is comparable to that observed for the same peptides on the induction of excessive grooming. |
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| Keywords: | Morphine ACTH Opiate receptor Analgesia |
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