| 幽门螺杆菌感染与胃癌及癌前病变中c-myc、p53、C-erbB-2及bcl-2蛋白表达关系的研究 |
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| 引用本文： | 瞿春莹,徐雷鸣,陈惠芳,李定国,姚晓虹,祝明洁.幽门螺杆菌感染与胃癌及癌前病变中c-myc、p53、C-erbB-2及bcl-2蛋白表达关系的研究[J].临床消化病杂志,2009,21(4):209-211,219. |
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| 作者姓名： | 瞿春莹 徐雷鸣 陈惠芳 李定国 姚晓虹 祝明洁 |
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| 作者单位： | 上海交通大学医学院附属新华医院,上海,200092 |
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| 摘 要： | 目的 观察胃癌、癌前病变中幽门螺杆菌(Hp)感染情况及其与c-myc、p53、c-erbB-2、bcl-2在胃癌及癌前病变中的表达关系,探讨Hp在胃癌、癌前病变发生及发展中的作用以及探索从癌前病变到癌变过程中的基因变化规律.方法 放大内镜及超声内镜检查收集103例胃黏膜标本,用免疫组织化学染色方法检测Hp感染及不同组织间c-myc、p53、c-erbB-2、bcl-2的表达.结果 c-myc、p53、c-erbB-2和bcl-2阳性表达率在胃癌组及癌前病变组中呈过度表达,与正常对照组相比有显著性差异(P<0.05).此外,Hp感染组c-myc、p53、c-erbB-2及bcl-2同时表达者为5例(9.4%);与无Hp感染组相比有显著性差异(P<0.01).结论 胃癌及癌前病变中组织存在c-myc、p53、c-erbB-2、bel-2多个表达,与Hp感染密切相关.
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| 关 键 词： | 胃癌 癌前病变 |
Clinic Study in c-myc,p53,c-erbB-2,bcl-2 Expression in Gastric Cancer and Precancerosis |
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| QU Chun-ying,XU Lei-ming,CHEN Hu-fang,LI Ding-guo,YAO Xiao-hong,ZHU Ming-jie.Clinic Study in c-myc,p53,c-erbB-2,bcl-2 Expression in Gastric Cancer and Precancerosis[J].Chinese Journal of Clinical Gastroenterology,2009,21(4):209-211,219. |
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| Authors: | QU Chun-ying XU Lei-ming CHEN Hu-fang LI Ding-guo YAO Xiao-hong ZHU Ming-jie |
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| Institution: | QU Chun-ying,XU Lei-ming,CHEN Hu-fang,LI Ding-guo,YAO Xiao-hong,ZHU Ming-jie Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China |
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| Abstract: | Objective To observe helicobacter pylori(Hp)infection in gastric cancer and precancerosis and its relationship with c-myc,p53,c-erbB-2,bcl-2 expression.Hp infection has an important effect in occurrence and development of gastric cancer,we approach genes alteration law in precancerosis transformation.Methods 103 speciments that we collected by EUS and magnifying chromogastrocopy were enrolled in the study.We detected the expression of c-myc,p53,c-erbB-2,bcl-2 in different tissues with or without Hp infectio... |
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| Keywords: | c-myc p53 c-erbB-2 bcl-2 |
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