| Aβ寡聚体与阿尔采末病及其靶点药物研究进展 |
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| 引用本文： | 刘明,辛现良,周瑞宇,杜晓光,耿美玉.Aβ寡聚体与阿尔采末病及其靶点药物研究进展[J].中国药理学通报,2008,24(12). |
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| 作者姓名： | 刘明 辛现良 周瑞宇 杜晓光 耿美玉 |
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| 作者单位： | 中国海洋大学医药学院,山东,青岛,266003 |
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| 基金项目： | 国家自然科学基金资助项目
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| 摘 要： | Aβ在阿尔采末病(AD)中起着重要的作用,寡聚化的Aβ分子被认为是AD发病的原发性因子,能够通过不同的机制发挥神经毒性作用,引发记忆损伤和神经元丢失,以Aβ为作用靶点的药物开发和应用也已初露端倪。该文对Aβ寡聚体在AD中的毒性作用和以Aβ为作用靶点的药物开发现状作一综述。
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| 关 键 词： | Aβ Aβ寡聚体 阿尔采末病 作用靶点 |
Progress in soluble Aβ oligomers in Alzheimer's disease and drugs targeting Aβ oligomers |
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| LIU Ming,XIN Xian-liang,ZHOU Rui-yu,DU Xiao-guang,GENG Mei-yu.Progress in soluble Aβ oligomers in Alzheimer''s disease and drugs targeting Aβ oligomers[J].Chinese Pharmacological Bulletin,2008,24(12). |
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| Authors: | LIU Ming XIN Xian-liang ZHOU Rui-yu DU Xiao-guang GENG Mei-yu |
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| Institution: | LIU Ming,XIN Xian-liang,ZHOU Rui-yu,DU Xiao-guang,GENG Mei-yu(School of Medicine , Pharmacy,Ocean University of China,Qingdao Sh,ong 266003,China) |
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| Abstract: | Aβ plays a crucial role in Alzheimer's Disease and the soluble Aβ oligomers have been recognized as the emerging neurotoxins,which ultimately cause memory impairment and neuronal loss through different mechanisms.The development of novel drugs targeting Aβ oligomers indicates new and promising therapy approaches for AD.The pathological roles as the proximal toxins in AD and the compounds,targeting soluble Aβ oligomers,which are currently in preclinical and early clinical development,are reviewed. |
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| Keywords: | Aβ Aβ oligomers Alzheimer's disease targets |
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